Completed projects

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Molecular mimics of meningococcal lipo-oligosaccharides as vaccine candidates

Royal Free Hospital, London, UK

Despite encouraging progress in the development of glycoconjugate vaccines against serogroup A and C meningococci, the development of an effective vaccine against serogroup B organisms remains a...

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The preterm infant's immune response to an acellular pertussis-Hib and meningitis C conjugate vaccine given together

Portsmouth Hospitals NHS Trust, Portsmouth, UK

100 infants born at 31 weeks gestation or less will be immunised with a combined three component acellular pertussis-HIB vaccine at the same time as a meningitis C conjugate vaccine at 2, 3 and 4...

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Macrophage migration inhibitory factor, high mobility group 1 and macrophage inhibitory cytokines in meningococcal disease in children

Alderhey Children's Hospital, Liverpool, UK

Despite more intensive medical management and the recent anti-endotoxin and cytokine therapies the mortality and morbidity of patients with meningococcal disease (MCD) remains significant.

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Meningococcal sugar as a helper to enhance performance of Group B vaccine candidates

University Medical Centre, Utrecht, The Netherlands

Prevention; University Medical Center, Utrecht.

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Development of a novel test for bacterial meningitis and septicaemia

Queen's Medical Centre, Nottingham, UK

Detection; Queen's Medical Centre, Nottingham

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Administration of new nerve-stimulating drugs to prevent hearing loss in bacterial meningitis.

Klinikum Grosshadern Ludwig Maximilians University, Munich, Germany

The most common severe long-term after effect of bacterial meningitis is deafness, which affects up to one third of survivors.

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